Since I have not taken it my chest feels so much better which is odd because chest pain is not listed as a side effect. Also I noticed that the Plaquenil I think was making me feel different but not in a good way. Malaria plaquenil Plaquenil retinopathy oct Chloroquine in lupus Does plaquenil work right away So, I asked about coming off of plaquenil. He said that I could stop plaquenil cold turkey. It slowly decreases effectiveness in the body. After the holidays, I am tempted to stop to see if the symptoms of lupus reappear so he can diagnose me. Did you ask to be put on a cancellation list for your new rheumy? Unfortunately, it's not a good idea to stop methotrexate "cold turkey.". Some people experience no side effects to suddenly stopping taking this medication, but it does have the potential for creating an intense RA flare. The goal of medication is to protect your joints and other systems in the body internal organs, such as the heart. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. Did you take yourself off Plaquenil, or did your doctor tell you to go off it? Plus I will be honest the whole eye site thing even though rare has always freaked me out. I went off of it to see if I can manage not being on it as my lupus isnt as severe as other cases but already I am feeling very fatigued and my legs feel heavy if that makes sense. I can discuss alternatives with my DR at my next appt but my DR feels as though the plaq is the best bet for my level of illness. If so are you just dealing with Lupus symptoms or did you take another med? I'm on Plaquenil, and after the first week's GI upset, I have had no problems with it. What could happen if you cold turkey plaquenil Fear of Plaquenil - Autoimmune Disorders - MedHelp, What Are The Side Effects Of Stopping Methotrexate? Chloroquine antimalarial side effectsChloroquine pubchemPlaquenil 2016Spotfin lionfish and chloroquine If you still have pain with your daily activities, then you and your doctor should think about trying another medicine. What are the side effects of Plaquenil? The most common side effects are diarrhea, nausea, vomiting, headache, dizziness, skin rash or black spots when you look at things. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. What is the correct way to discontinue use of plaquenil?. Cold Turkey’ Alcohol Withdrawal Can Cause Serious Health.. I have been reading up on stress and what that can cause and do to a person. My body feels so much better, what do you make of this? Thank you, Loretta. Answer. There is no problem with stopping methotrexate abruptly, with the exception that you might flare if you indeed have active ongoing RA. Talk to your rheumatologist If you are taking hydroxychloroquine for symptoms of rheumatoid arthritis, your symptoms should improve within 6 months. If your rheumatoid arthritis symptoms do not improve, or if they worsen, stop taking the drug and call your doctor. Once you and your doctor are sure the drug works for you. Withdrawal Symptoms. When the body adjusts to the presence of a medication, it develops a dependence on the drug in which the body needs the drugs in order to feel normal. When the medication is stopped, the body recognizes that it is missing what has become normal. 1.