These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Sore bum with hydroxychloroquine Chloroquine 250 Plaquenil prsivribed by rheumatilogshrs cut in half Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Or shorter - up to 200 mg Plaquenil daily; Women with lupus who are AT OR BELOW their ideal body weight should go by these dosing rules 135 lbs. or more, any height - up to 400 mg Plaquenil daily; 102 lbs. to 134 lbs. - up to 300 mg Plaquenil daily; 101 lbs or less - up to 200 mg Plaquenil daily; A lupus patient explains her changes in vision Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. If you notice any other effects, check with your healthcare professional. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Stopping plaquenil effects Hydroxychloroquine Oral Route Side Effects - Mayo Clinic, Protecting your eyesight when taking Plaquenil Lupus. Plaquenil myalgias In Stop Sarcoidosis My pulmonist started me on high doses of prednisone in 1999, he would start to decrease, and he would tell me I am not responding to the decrease. Methotrexate and side effects In Stop Sarcoidosis Have just had my second dose of methotrexate and have had side effects already. Side effects to Stopping Plaquenil. - Sarcoidosis - Inspire. Long-Term Side Effects of Plaquenil for Rheumatoid.. Plaquenil Withdrawal – Life As An Anomaly. Tell your doctor if any of the following side effects, as they may be indications of a more serious reaction Headache. Loss of appetite. Dizziness. Nausea. Diarrhea, vomiting, or stomach pain. Skin rash. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. Plaquenil toxicity isn’t even in the top 10, or the top 100” if you’re looking at incidence, he said. “It’s a pretty rare thing.” Nevertheless, he urged doctors to master the Academy’s new guidelines, because the effects from chloroquine and hydroxychloroquine, when they do occur, are severe and often irreversible.