It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Chloroquine combination therapy Plaquenil toxicity macula Hydroxychloroquine in pregnancy and lactation Hydroxychloroquine Pregnancy Warnings Animal studies have revealed evidence of fetal harm. Use of chloroquine and other 4-aminoquinolines in high doses and for prolonged durations has been associated with neurological disturbances and interference with hearing, balance, and vision in the fetus. Could taking hydroxychloroquine help prevent pregnancy complications? Hydroxychloroquine may benefit pregnancies by reducing active disease of lupus. Hydroxychloroquine may also reduce the chance for a baby to be born with a specific heart conduction problem, called congenital heart block. OBJECTIVE The use of hydroxychloroquine HCQ in pregnancy remains controversial. The recent demonstration that HCQ passes across the placenta, with cord blood concentrations nearly identical to those found in maternal blood, emphasizes the need for careful evaluation of pregnancies in women receiving HCQ. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Pregnancy hydroxychloroquine Plaquenil Hydroxychloroquine - Side Effects, Dosage., Hydroxychloroquine MotherToBaby What to expect when stop taking plaquenilChloroquine treatment of amoebic liver abscessCan i take plaquenil and lisinopril togetherChloroquine regimen It is not necessary to withdraw an antimalarial drug during pregnancy if the rheumatic disease is well controlled; however, the manufacturer of hydroxychloroquine advises avoiding use. Breast feeding Avoid—risk of toxicity in infant. HYDROXYCHLOROQUINE SULFATE Drug BNF content published by NICE. Safety of hydroxychloroquine in pregnant patients with.. Hydroxychloroquine Oral Uses, Side Effects, Interactions.. It does not appear to be safe during pregnancy. Hydroxychloroquine is in the antimalarial and 4-aminoquinoline families of medication. Hydroxychloroquine was approved for medical use in the United States in 1955. May 13, 2009 The anti-malarial drugs Hydroxychloroquine HCQ is widely used to treat various rheumatic diseases mechanism of action of this drug is to increase the pH in acidic vesicles, inhibiting receptor mediated endocytosis that affects many cellular functions including antigen presentation, toll receptor signaling and post-transcriptional modification of proteins 2–4. ATLANTA – Hydroxychloroquine Plaquenil 400 mg/day starting by pregnancy week 10 reduces recurrence of congenital heart block in infants born to women with anti-Ro antibodies, according to an open-label, prospective study presented at the annual meeting of the American College of Rheumatology.