In addition, the impact of the patient’s physiopathological status and ethnic origin on chloroquine pharmacokinetics is discussed. In humans, chloroquine concentrations decline multiexponentially. The drug is extensively distributed, with a volume of distribution of 200 to 800 L/kg when calculated from plasma concentrations and 200 L/kg when estimated from whole blood data (concentrations being 5 to 10 times higher). Plaquenil 200 mg pill How chloroquine causes itch What is the nursing intervention for hydroxychloroquine Mechanism of chloroquine on lysosome Desethylchloroquine and bisdesethylchloroquine concentrations reach 40 and 10% of chloroquine concentrations, respectively; both chloroquine and desethylchloroquine concentrations decline slowly, with elimination half-lives of 20 to 60 days. Both parent drug and metabolite can be detected in urine months after a single dose. In contrast to quinine which has a relatively limited apparent volume of distribution approximately 2.51/kg in healthy adults and short elimination half-life 11 hours in healthy subjects, 16 hours in cerebral malaria, chloroquine has an enormous total apparent volume of distribution 100–10001/kg and a terminal elimination half-life of approximately one month White et al. 1985. The pharmacokinetic properties of chloroquine are complex; distribution rather than elimination processes. The plasma half-life of chloroquine in healthy individuals is generally reported to be 72-120 hr. In one study, serum concentrations of chloroquine appeared to decline in a biphasic manner and the serum half-life of the terminal phase increased with higher dosage of the drug. Following administration chloroquine is rapidly dealkylated via cytochrome P450 enzymes (CYP) into the pharmacologically active desethylchloroquine and bisdesethylchloroquine. Chloroquine is 60% bound to plasma proteins and equally cleared by the kidney and liver. Half life of chloroquine How medicines are made pharmacokinetics through the lens of., Chloroquine - an overview ScienceDirect Topics Buy hydroxychloroquine ukPlaquenil where to buyHydroxychloroquine rheumatoid arthritis One study indicated that chloroquine declines in a biphasic manner, with the terminal phase half-life increasing with increasing doses, as follows 3.1 hours after a single 250-mg oral dose, 42.9 hours after a single 500-mg oral dose, and 312 hours after a single 1-g oral dose. Chloroquine Information for Providers AIDSinfo. Chloroquine C18H26ClN3 - PubChem. Chloroquine DermNet NZ. An analog of chloroquine – hydroxychloroquine – has a long half-life 32–56 days in blood and a large volume of distribution 580–815 L/kg. The therapeutic, toxic and lethal ranges are usually considered to be 0.03 to 15 mg/l, 3.0 to 26 mg/l and 20 to 104 mg/l, respectively. Prolonged half life of several weeks 50% of chloroquine is excreted unchanged; Resuscitation Coma Prompt intubation and ventilation, if acidaemia exists, give sodium bicarbonate 1 – 2 mmol/Kg IV to prevent further toxicity during intubation. End goals should be a narrow QRS 100ms and a pH 7.45 Half-life time of this drug is approximately 18 hours in vivo due to the degradation by the liver, but the stability of chloroquine in vitro experiments is expected to be longer.