The patient had been on Amiodarone therapy for several years. These deposits occur in various levels of the cornea. Two months prior to this routine follow up, the patient's primary care doctor made a change in the patient's cardiac medications which included the removal of amiodarone from his medication regimen. Corneal verticillata, also called vortex keratopathy, are one type of corneal deposits. Plaquenil antibiotic Skin side effects of plaquenil Plaquenil kidney side effects Progression of vortex keratopathy VK causes increasing haloes and blur but is fully reversible upon discontinuation of therapy. Complications Even when the clinician and patient adhere to screening guidelines and retinopathy is detected in a sub-clinical stage, discontinuation of chloroquine or hydroxychloroquine therapy may not stop the progression of retinopathy to a stage where the patient loses vision. Fidanoski.ca The long-term administration of hydroxychloroquine HCQ sulfate is well known to be associated with AE, such as vortex keratopathy and in particular the often irreversiblenih.gov keratopathy and maculopathy. Corneal deposits called vortex keratopathy or corneal verticillata result from binding to cellular lipids and deposition of the drug in the basal epithelial layer of the cornea. Discontinuation of the drug usually causes the deposits to disappear over time. The opacities branch out from a central whorl, usually across the inferior cornea. Verticillata are readily recognizable by their distinct appearance as fine, golden-brown or gray opacities that are almost always bilateral. Vortex keratopathy hydroxychloroquine Cornea Verticillata - EyeWiki, Hepatomegaly & Vortex Keratopathy Causes & Reasons - Symptoma® What are the side effects of plaquenilPlaquenil treatment rheumatoid arthritisWill plaquenil help with memoryHydroxychloroquine eliminationPlaquenil dose for malaria prevention A number of prescription drugs are well known for their potential retinal toxicity, including Plaquenil hydroxychloroquine, Sanofi Aventis, tamoxifen and thioridazine.1 Vortex keratopathy has been linked to use of amiodarone and indomethacin.2 Anti-anxiety medications, such as Prozac fluoxetine, Eli Lilly and Zoloft sertraline, Pfizer. When OTC is Not OK. Chloroquine And Hydroxychloroquine Toxicity. Corneal verticillata - American Academy of Ophthalmology. The cornea may become affected relatively commonly by an innocuous vortex keratopathy and is characterized by whorl-like corneal epithelial deposits. These changes bear no relationship to dosage and are usually reversible on cessation of hydroxychloroquine. In 1 case related to perhexiline maleate, papilledema appearing concurrently with the vortex keratopathy and considered drug related resulted in significant visual acuity loss that did not completely reverse after withdrawal of the drug. 24 Besides asymptomatic vortex keratopathy, retinal toxicity—including macular and peripheral retina. Toxicity from hydroxychloroquine may be seen in two distinct areas of the eye the cornea and the macula. The cornea may become affected relatively commonly by an innocuous cornea verticillata or vortex keratopathy and is characterized by whorl-like corneal epithelial deposits. These changes bear no relationship to dosage and are usually reversible on cessation of hydroxychloroquine.