I'm not completely pain free, but it's a lot better than it was. I've been on plaquenil since mid June I have had a lot of stress in my life so I can't determine what is causing what. Not seeing any improvements with pain but I just went to 0 prednisone 3 weeks ago. said give it a few months and if I don't see any improvement I might as well go off of it. Wanted to let you know that I was on plaquenil for about three years and I told my RA doctor that my fatigue was worse. It just seems like the fatigue is worse than it has ever been, and it doesn't seem to matter if I go to bed early or take a nap during the day. Woke up and cleaned the kitchen an hour later(my kitchen is a galley kitchen 8 ft maybe.no time) Took a nap. Early on I did get those stomach cramps and diarrhea. All my pain is tolerable and he sees no deformities so he says he doesn't see RA activity. Just because the pain is tolerable doesn't make me like it any better. He did a plaquenil test and sure enough it was low. Trametinib and hydroxychloroquine Treatment rheumatoid arthritis with methotrexate and hydroxychloroquine I started on Plaquenil again. I stopped taking it the first time because my stomach hurt so bad. My rheumy said to just take a half a pill right now 100 mg. It's been about a week now and I am noticing dizziness, fatigue and just kind of weak. Can this be a side effect of Plaquenil when you first start? I don't recall it happening last time. I have been on Plaquenil for years. It has not helped me with fatigue. Things like vitamins and exercise might assist with decreasing the fatigue level. I have been on 2 Dmards and a biologic for the longest time. I also take Tramadol for pain and now Indomethicin has been added to the mix to help with stiffness. Fatigue is often described as one of the most debilitating symptoms of Sjögren’s. I long for normal energy and the ability to sustain activity, any activity. I long for the kind of fatigue that gets better with a good night's sleep. I want to be able to do things spontaneously. I wake up tired in the morning, get my kids fed and off to the schoolbus, and some days that's all I can do until it's time to go pick them up and make dinner, then I collapse after the kids are put to bed. I don't know if this is just the way RA is, or if it is a side effect of the medicine. Wasn't going to eat luch because I would have to move to do it.husband bought out. Kids came home, helped with homewrok, made dinner..picked up couch(because my blanket and pillow were there) Went to bed at 9. Plaquenil sjogren's fatigue Management of Systemic Features of Sjögren’s Syndrome Johns., Plaquenil for fatigue and pain DailyStrength Hydroxychloroquine and bronchiecstasisPlaquenil and mobicPlaquenil tableChloroquine iupac nameHydroxychloroquine sulfate online washington dc Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine Plaquenil. Types of Sjögren’s Fatigue - info.. Is extreme fatigue a side effect of Plaquenil?. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Fatigue Fatigue is most effectively managed with self-care measures and exercise. Exercise provides similar benefit to reduce fatigue in Sjögren’s patients as was seen for those with RA, SLE or Multiple Sclerosis. Systemic Manifestations in Sjögren’s Patients This is important as wheat allergy is positive in 14.7% of those with Sjogren's vs. only 1% of the general population.8 Treating the Pain and Fatigue. If the patient has widespread pain and fatigue in Sjogren's, there is a significant chance that they also have lupus, rheumatoid arthritis RA or fibromyalgia.