Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine skin darkening Chloroquine brazil Immune thrombocytopenia usually happens when your immune system mistakenly attacks and destroys platelets, which are cell fragments that help blood clot. In adults, this may be triggered by infection with HIV, hepatitis or H. pylori — the type of bacteria that causes stomach ulcers. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur. A low platelet count is a blood disorder that can sometimes be serious. This article looks at platelets and their role within the body. Find out about the many possible causes of a low count. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil thrombocytopenia Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus, Plaquenil Side Effects Common, Severe, Long Term - Chloroquine hyposalinityHow long does it take plaquenil to leave your systemCan i take ginseng if i'm am on plaquenilPlaquenil and orthopedic surgery If any severe blood disorder such as aplastic anemia, agranulocytosis, leukopenia, or thrombocytopenia, appears which is not attributable to the disease under treatment, consider discontinuation of Plaquenil. Plaquenil should be administered with caution in patients having glucose-6-phosphate dehydrogenase G-6-PD deficiency. Plaquenil - FDA prescribing information, side effects and uses. Low platelet count thrombocytopenia Causes, treatment, and.. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Thrombocytopenia is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Enbrel, and have High blood pressure Immune thrombocytopenia is an autoimmune disease in which platelets are targeted by the host immune system. Platelet depletion occurs when autoantibodies targeting glycoproteins found on the surface of platelets opsonize the cells, resulting in destruction by macrophages.