This medicine is also sometimes given off-label to help the following conditions: Also, let your doctor know if you drink large amounts of alcohol before starting on this medicine. Your doctor will probably want to order frequent tests to check your body's response to chloroquine. Major issue with chloroquine Plaquenil itchy rash Plaquenil pregnancy class Hydroxychloroquine retinal toxicity retina replacement Oral Dosage Forms That Should Not Be Crushed February 21, 2020 The List of Oral Dosage Forms That Should Not Be Crushed, commonly referred to as the "Do Not Crush" list, contains medications that should not be crushed because of their special pharmaceutical formulations or characteristics, such as oral dosage forms that are sustained-release. Irreversible retinal damage observed in some patients who had received hydroxychloroquine sulfate; significant risk factors for retinal damage include daily doses of hydroxychloroquine sulfate greater than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than five years, subnormal glomerular filtration. The standard chloroquine dose for treating malaria in adults is a one-time loading dose of 1000 mg, followed by 500 mg in six to eight hours. Then 500 mg is taken once a day for two more days. The standard dosage for malaria treatment in children is based on the child's weight. Let your healthcare provider know if your symptoms either don't improve or worsen while taking this medicine. Keep all appointments with your doctor and laboratory. Chloroquine dosage forms Chloroquine Oral Route Description and Brand Names., Plaquenil hydroxychloroquine sulfate dosing, indications. Oral plaquenil In one study, serum concentrations of chloroquine appeared to decline in a biphasic manner and the serum half-life of the terminal phase increased with higher dosage of the drug. In this study, the terminal half-life of chloroquine was 3.1 hr after a single 250 mg oral dose, 42.9 hr after a single 500 mg oral dose. Chloroquine C18H26ClN3 - PubChem. Chloroquine Dosage - Malaria Home Page. Chloroquine Oral Route Proper Use - Mayo Clinic. The dosage of chloroquine phosphate is often expressed in terms of equivalent chloroquine base. Each 500 mg tablet of ARALEN contains the equivalent of 300 mg chloroquine base. In infants and children the dosage is preferably calculated by body weight. Malaria. Suppression — Adult Dose 500 mg = 300 mg base on exactly the same day of each week. Chloroquine is a 4-aminoquinoline which has marked, rapid schizontocidal activity against blood forms of P. ovale and P. malariae and against susceptible strains of P. vivax and P. falciparum. It is also gametocytocidal against P. vivax, P. ovale and P. malariae and immature P. falciparum. Available Dosage Forms Tablet; Therapeutic Class Antimalarial. Chemical Class Aminoquinoline. Uses for chloroquine. Chloroquine is used to prevent and treat malaria. It is also used to treat liver infection caused by protozoa extraintestinal amebiasis. Chloroquine belongs to a group of medicines known as antimalarials.