Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Chloroquine aralen drug card Plaquenil side effects anti depressants May 02, 2007 They have to examine you to see if you have anything of concern that they can determine that is NOT caused by Plaquenil which is why the baseline exam is important. If your exam showed something after taking the Plaq, then they would not be able to determine if it was caused by Plaq or was pre-existent. Most rheumatologists recommend patients undergo a baseline eye examination prior to starting Plaquenil and be re-examined in the future depending on their risk for developing the condition. Risk factors include advanced age and having pre-existing retinal disease. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells. Rare but potentially serious eye toxicity can occur. This toxicity affects a part of the eye called the retina and can lead to color blindness and even loss of vision. An ophthalmologist eye specialist often can detect changes in the retina that suggest toxicity before serious damage occurs. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). Do you need a baseline eye exam before taking hydroxychloroquine Hydroxychloroquine Plaquenil, Plaquenil Side Effects on Your Eyes and Vision Plaquenil and antidepressantsHydroxychloroquine gingival hyperplasia Plaquenil is the one drug that you need the eye exam prior to starting the drug as they really need that baseline. If it's going to affect your eyes, tends to do so in the first 6 months. but I don't think MTX is the same.doc hasn't made me get it prior to treatment but he is adamant about yearly eye exams. Bone Joint Muscle - Arthritis Baseline eye exam and Methotrexate. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Stonewire Optometry-Blog-Hydroxychloroquine Why you need an.. Hydroxychloroquine, on the other hand, is much less toxic to the retina and there have been fewer reported eye problems. In general, a baseline ophthalmic examination should be performed upon initiation of therapy. In addition, a central visual field test and color photographs of the retina are usually taken at that time. Otherwise, you should have a check up with an optician once a year and tell them that you're taking hydroxychloroquine. You should report any new eye symptoms to your doctor straight away. If you develop any other new symptoms or there's anything else that concerns you after starting hydroxychloroquine, you should tell your doctor or rheumatology nurse specialist as soon as possible. Dec 17, 2018 Follow these guidelines to get your child screened at the right times. These screenings help identify when your child might need a complete eye exam. Baseline eye exams for adults. The American Academy of Ophthalmology recommends that adults get a complete eye examination at age 40. This is when early signs of disease or changes in vision may.