I currently take 6 tablets a week and I started taking them in February this year . Has anyone been through the same as me, and find that the meds simply haven't worked so you have to simply start again. I have called my nurse specialist but she hasn't got back yet. Hang in there- it's very early days x I'm afraid Jacki08 is right it's early days and these meds take time. I am still in a lot of pain I have immense fatigue and feel miserable. I started MTX in September along with naproxen and gradually built up to 8 tablets (20mg) a week by the end of December. Médicament mylan-hydroxychloroquine Clinical pharmacokinetics and metabolism of chloroquine Plaquenil 2016 Love plaquenil I have also tried hydroxychloroquine and sulfazalazine both of which caused tinnitus so had to come off them. My consultant has now put my methotrexate up to 25mg to see if my symptoms improve. I'm trying to stay positive but if this doesn't work what other treatment is there. it is so annoying as the combination of methotrexate and. It is licensed in the UK for the treatment of malaria. Hydroxychloroquine is particularly effective for systemic lupus erythematosus SLE and discoid lupus erythematosus DLE. By reducing inflammation, hydroxychloroquine can decrease pain, swelling and stiffness of joints, and improve or clear some rashes. Re Plaquenil not working anymore Lizzy, I took 400mg 200 twice a day for 16-18 months forget exact duration, then was reduced to 200 mg daily. But right from the start, I also needed NSAID's for pain. Things have been in their stride since mid February and now it's looking good regarding fatigue, swelling and pain (though I only ever had a little pain compared to what others have described). I started taking mthx in October last year and expected results quite quickly. Hydroxychloroquine not working what next Hydroxychloroquine User Reviews for Rheumatoid Arthritis at., Hydroxychloroquine Skin Support Chemical structure of chloroquineChloroquine together with proguanilDoes plaquenil stop joint destruction in ra I just started treatment myself about 2 months ago and intially all my doctor told me to do was to take motrin 800 daily for the next 3 weeks until my blood work came back. I know there are certain things that they look at from your blood work before they decide to start you on the heavy hitters. Prednisone Not Working?" Rheumatoid Arthritis Community.. Immune & Autoimmune - Lupus Plaquenil not working anymore. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Hi ya, I remember the frustration at the beginning, they started me on 8 tablets, didn't do much for 4 months so upped me to 10, after another 3-4 months it did start to help watch out for mouth ulcers, mine were horrendous, needed 6 x folic acid tablets a week to keep them at bay. Generally, hydroxychloroquine is given in 200 mg or 400 mg doses, once per day. Higher doses can sometimes be used, but only in adults and not for all cases. What next if plaquenil doesn't work? Support Forums. I have to have liver and crp retest next week. My hair is coming out slightly Not in clumps are anything, just a little here or there. Really though in order not to have worse things happen it is what we have to do. I know it is scary but anything to stop the pain and misfunction of not.