Just google does low dose naltrexone cause a herxheimer's reaction and I am sure you will find a lot of info. Did you have your med compounded from pure naltrexone powder or from ground up 50 mg Revia/generic equivalent? Here is how it applies to AP https://en.wikipedia.org/wiki/Type_III_hypersensitivity https://chronicillnessrecovery.org/index.php? Hi, Boise CGM- Can you please describe the "awful"? Happy to help if you can provide a few key details. Lupus treatment hydroxychloroquine Plaquenil side effects from the n eyes Plaquenil deplete magnesium Chloroquine reduce cell viability It might be a bit of heartburn or gastritis. Make sure though to wait 2 hrs before and 2hrs after taking the plaquenil to take an antacid. Watch that sun. I find I feel worse when I've had too much of it. I'm prone to itching like crazy after too much sun. Are you using a broad spectrum sunscreen and UV protective clothing hat too? Hello kelpie21, It can be a hard road, can't it? Hydroxychloroquine does take a while to take effect. Arthritis UK gives a figure of around 12 weeks, whilst the American College of Rheumatology says, "symptoms can start to improve after 1-2 months, but it may take up to 6 months before the full benefits are felt". I recently decided to stop taking Plaquenil because I was having constant chest pains even more so than I usually have due to Lupus. Since I have not taken it my chest feels so much better which is odd because chest pain is not listed as a side effect. Also I noticed that the Plaquenil I think was making me feel different but not in a good way. He's excellent, open-minded, and in my opinion quite brilliant - and had the following comment when I asked him about LDN in an email. Kk I've quoted my scleroderma specialist on LDN here before, but will copy and paste it again. Will i feel worse before i feel better on plaquenil Study Raises Questions about Sjogren's and Plaquenil, How long until Hydroxychloroquine takes effect - LUPUS UK Hydroxychloroquine cystic fibrosisHydroxychloroquine drugbankPlaquenil structureChloroquine for malaria treatment Hi Guys, I haven't been here for a while - just checked in and found this question on Plaquenil - for me it took approx nine weeks to begin to work - I'm only taking 200mg per day so far - it seemed to stop working a few weeks later - most days are pretty good I s'pose but I drop nearly every afternoon. Immune & Autoimmune - Lupus Plaquenil - Can It Work Quickly?. Had to stop taking Plaquenil -. Hydroxychloroquine Reviews Everyday Health. I could no longer afford to see him or the other specialists I was seeing. The worst effect that I am aware of is the fact that my teeth have gotten progressively worse and keep breaking off at the gum line. I don't know whether it's the plaquenil or not, but my hair became really wavy and I had always had very straight hair before. F 61 2 years Hello friends, I take my Plaquenil in the morning with breakfast. I feel very shaky, dizzy and just off all day. Does anyone take it at night? Will it keep me up? Why do I have to take it in the morning. Plaquenil hydroxychloroquine "When first diagnosed with rheumatoid arthritis RA plaquinel worked after a couple weeks. I was in remission soI stopped but Dr upset as he said it was important to keep damage to joints down. Anyway the RA flared and I'm back taking one a day. Hoping to feel better again but seems slow.