Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. What does plaquenil help Plaquenil and pancreatitis What concentration does plaquenil come in Blood monitoring hydroxychloroquine Chloroquine is a medication first developed as an anti-malarial that has been used for many years to help treat lupus systemic lupus erythematosus, or SLE and rheumatoid arthritis. If a patient responds to treatment with an anti-malarial, in general it will continue to be used indefinitely. Most physicians with experience in lupus agree that antimalarial treatments such as hydroxychloroquine Plaquenil, chloroquine Aralen or quinicrine Atabrine should be used long-term, year-after-year, in all lupus patients who can tolerate them. In SLE patients the cytokine levels were measured just before and three months after starting chloroquine treatment at a dose of 125 mg twice daily. Although the majority of SLE patients had a low systemic lupus activity measure SLAM index, the levels of IL-6, IL-18 and TNF-alpha were significantly higher than in the control group. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine use in sle Hydroxychloroquine DermNet NZ, Why are treatments that were developed for malaria now. Plaquenil side effects antimalarial Leukopenia, which frequently occurs in patients with systemic lupus erythematosus, is usually not severe i.e. white blood cell count of less than 1,000 × 10 3 per mm 3 1.0 × 10 9 per L and rarely requires treatment. Thrombocytopenia, if stable, and if the platelet count remains above 50,000 × 10 3 per mm 3. Treatment of Systemic Lupus Erythematosus An Update - American Family.. Chloroquine treatment influences proinflammatory cytokine.. Treatment of SLE in pregnancy and use of Chloroquine The BMJ. Use of GCs has improved the outlook of SLE, limiting their use is of equal importance, since evidence is accumulating that GCs might contribute to irreversible damage Al Sawah, 2015. Interestingly, the initial dose of prednisone in the first month of treatment is predictive of the prednisone doses over the following 11 Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. ovale, and P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine is an aminoquinoline used for the prevention and therapy of malaria. It is also effective in extraintestinal amebiasis and as an antiinflammatory agent for therapy of rheumatoid arthritis and lupus erythematosus.