In a large, case-control study of elderly patients, those who used corticosteroids and NSAIDs concurrently had an estimated relative risk (RR) for peptic ulcer disease and GI hemorrhage of 14.6 compared to those who used neither. Oral corticosteroid use was associated with a doubling of the risk (estimated RR = 2.0), but the risk was confined to those who also used NSAIDs. Plaquenil with percocet Plaquenil screening doctor Adverse effects of chloroquine Chloroquine drug adverse effects When my wife was first diagnosed with PMR in May, 2016, she was put on 15mg Pred. A month later, she was told to take 400mg of plaquenil daily, with the understanding that plaquenil would replace prednisone eventually. This rheumy tried to get her down to 5mg six months later, which was a total mistake. I started on Hydroxychloroquine and prednisone at the end of December. Just saw rheumy yesterday because the prednisone wasn't having any affect on 20 mg/day and my rheumy didn't want to increase the prednisone any higher. So she has put me on methotrexate. She said I can take the dose all at. My Mom's Dr's wan'ts her to take both Prednisone and Plaquenil together. I have not heard of this being done. I was wondering if anyone has done both med's at the same time and the effects. Mom has Lupus like me, but she was diagnosed when she was 40 yrs old and now she is 58. She has and enlarged heart, diabetes, had a stroke, and failing kidneys. MANAGEMENT: Caution is advised if oral corticosteroids and NSAIDs are used together, especially in patients with a prior history of peptic ulcer disease or GI bleeding and in elderly and debilitated patients. It is possible that both categories of agents are ulcerogenic and have additive effects on the GI mucosa during coadministration. Some investigators have also suggested that the primary effect of corticosteroids in this interaction is to delay healing of erosions caused by NSAIDs rather than cause de novo ulcerations. Can i take prednisone and hydroxychloroquine together Prednisone and Hydroxychloroquine sulfate drug interactions., Hydroxychloroquine & Methotrexate DailyStrength Hydroxychloroquine 200mg equivalentPlaquenil and heartburn Does Prednisone Interact with other Medications? Severe Interactions. These medications are not usually taken together. Consult your healthcare professional e.g. doctor or pharmacist for more. Prednisone Oral Interactions with Other Medication. Prednisone and plaquenil -. Plaquenil Oral Interactions with Other Medication. Whether a person can drink alcohol while taking prednisone depends on a range of factors, including the length of the treatment, the dosage, and how much alcohol they drink. Learn more here. I take both prednisone and plaquenil. I heard someone once say that prednisone is the drug one loves to hate. It really does wonders to control inflammation, but has nasty side effects when given in large doses and/or used for a long period of time. My first experience with prednisone was horrific I was on 60mg per day, then on to 50, then 40. Has anyone's doctor suggested taking plaquenil to help taper off Rheum thinks that plaquenil will help me get to a lower dose of prednisone since I can't get past 7.5 mg without a flare.