Chloroquine poisoning

Discussion in 'Canadian Pharmacy' started by Stokd, 25-Feb-2020.

  1. searchseo Guest

    Chloroquine poisoning


    One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

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    Mar 15, 2019 Chloroquine and Hydroxychloroquine Toxicity Treatment & Management Approach Considerations. Withdrawal of the medication and shifting to another form. Deterrence/Prevention. During therapy, patients should be monitored on an annual basis starting. Long-Term Monitoring. A yearly visual field. Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. In small children, the ingestion of 1-2 tablets of chloroquine is a potentially life-threatening ingestion. Chloroquine is on the list of ‘two pills that can kill‘ toddlers. The worst case scenario is an ingestion of 310mg/15kg = ~21 mg/kg.

    It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress.

    Chloroquine poisoning

    Chloroquine - FDA prescribing information, side effects and uses, Chloroquine and Hydroxychloroquine Toxicity Practice.

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  6. CONCLUSIONS The mortality rate in patients with acute chloroquine poisoning, including those patients sick enough to be referred to a specialty unit such as ours, can be limited to or = 10%. This finding appears to be true even in patients with massive ingestions.

    • Treatment of acute chloroquine poisoning a 5-year experience..
    • Chloroquine poisoning • LITFL • Clinical Case Tox Conundrum.
    • Chloroquine poisoning. Rapidly fatal without treatment. The BMJ.

    Chloroquine has to be considered to be useful for fatal poisoning, which is also recommended in some publications on methods to commit suicide. Chloroquine and hydroxychloroquine cause vasodilation and myocardial depression. Epinephrine has been shown to decrease the effects of chlorquine on the myocardium in animals and humans. It acts as a potent inotropic agent and vasoconstrictor. The dose recommended by Riou et al is 0.25 mcg/kg/min. Abstract No therapy has been proved to be effective for patients with severe chloroquine poisoning, which is usually fatal. In a retrospective study of 51 cases, we found that ingestion of more tha.

     
  7. QLE.RU Well-Known Member

    This is not a list of all drugs or health problems that interact with chloroquine. Chloroquine mode of action. MY SEMINAR on authorSTREAM Antimalarial drugs - SlideShare
     
  8. vikpis XenForo Moderator

    Chloroquine Indications, Side Effects, Warnings - This medicine may add to the chance of getting some types of cancer. Talk with the doctor. Keep away from children. Accidental exposure may cause death. If a child takes chloroquine by accident, get medical help right away. If you are 65 or older, use chloroquine with care. You could have more side effects.

    Chloroquine & Hydroxychloroquine supporting chemo.
     
  9. Eugene_E_N Well-Known Member

    Alcohol and Arthritis Medications - Verywell Health DMARDs include methotrexate and Arava leflunomide, Azulfidine sulfasalazine, and Plaquenil hydroxychloroquine. Patients taking methotrexate are advised to avoid alcohol, including beer, wine, and hard liquor, because of the increased risk of liver disease. 

    Methotrexate Rheumatrex, Trexall