One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Allergic to plaquenil Plaquenil cessation Does plaquenil reduce spleen inflammation Mar 15, 2019 Chloroquine and Hydroxychloroquine Toxicity Treatment & Management Approach Considerations. Withdrawal of the medication and shifting to another form. Deterrence/Prevention. During therapy, patients should be monitored on an annual basis starting. Long-Term Monitoring. A yearly visual field. Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. In small children, the ingestion of 1-2 tablets of chloroquine is a potentially life-threatening ingestion. Chloroquine is on the list of ‘two pills that can kill‘ toddlers. The worst case scenario is an ingestion of 310mg/15kg = ~21 mg/kg. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Chloroquine poisoning Chloroquine - FDA prescribing information, side effects and uses, Chloroquine and Hydroxychloroquine Toxicity Practice. Does hydroxychloroquine cause health problemsPlaquenil night visionChloroquine brandsChloroquine and p62 CONCLUSIONS The mortality rate in patients with acute chloroquine poisoning, including those patients sick enough to be referred to a specialty unit such as ours, can be limited to or = 10%. This finding appears to be true even in patients with massive ingestions. Treatment of acute chloroquine poisoning a 5-year experience.. Chloroquine poisoning • LITFL • Clinical Case Tox Conundrum. Chloroquine poisoning. Rapidly fatal without treatment. The BMJ. Chloroquine has to be considered to be useful for fatal poisoning, which is also recommended in some publications on methods to commit suicide. Chloroquine and hydroxychloroquine cause vasodilation and myocardial depression. Epinephrine has been shown to decrease the effects of chlorquine on the myocardium in animals and humans. It acts as a potent inotropic agent and vasoconstrictor. The dose recommended by Riou et al is 0.25 mcg/kg/min. Abstract No therapy has been proved to be effective for patients with severe chloroquine poisoning, which is usually fatal. In a retrospective study of 51 cases, we found that ingestion of more tha.