Plasmodium falciparum chloroquine resistance transporter

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  1. Bu-Bu XenForo Moderator

    Plasmodium falciparum chloroquine resistance transporter


    This score cannot be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry.

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    Chloroquine CQ has been used for decades as the primary chemotherapeutic drug for the treatment of malaria. The emergence of drug resistance in Plasmodium falciparum has been considered to be because of the excessive use of antimalarial drugs worldwide. Moreover, the intense distribution and prevalence of chloroquine-resistant strains in endemic regions has aided the incidence of more. Background Plasmodium falciparum existence continues to develop resistance to conventional antimalaria drugs in malaria endemic areas. Plasmodia often prevent drugs from interacting with the target site, hence, developing resistance to antimalaria drugs. Mutations in the Plasmodium falciparum chloroquine resistance transporter Pfcrt, are the major determinant of chloroquine resistance in. Cooper RA, Lane KD, Deng B, Mu J, Patel JJ, et al. 2007 Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine. Mol Microbiol 63 270–282. View Article Google Scholar 18.

    This is known as the 'taxonomic identifier' or 'taxid'. This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. Cyclic redundancy and other checksums Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)) AF030694 Genomic DNA Translation: AAF26926.1AF233064 m RNA Translation: AAF60271.1AF233065 m RNA Translation: AAF60272.1AF233066 m RNA Translation: AAF60273.1AF233067 m RNA Translation: AAF60274.1AF233068 m RNA Translation: AAF60275.1AF495376 Genomic DNA Translation: AAO85506.1AF495377 Genomic DNA Translation: AAO85507.1AF495378 Genomic DNA Translation: AAO85508.1AY651315 m RNA Translation: AAU00067.1AF468006 m RNA Translation: AAL75580.1DQ156107 m RNA Translation: AAZ81606.1DQ156108 m RNA Translation: AAZ81607.1DQ156109 m RNA Translation: AAZ81608.1DQ533840 m RNA Translation: ABF82363.1AY254700 m RNA Translation: AAP79044.1AF030694 Genomic DNA Translation: AAF26926.1AF233064 m RNA Translation: AAF60271.1AF233065 m RNA Translation: AAF60272.1AF233066 m RNA Translation: AAF60273.1AF233067 m RNA Translation: AAF60274.1AF233068 m RNA Translation: AAF60275.1AF495376 Genomic DNA Translation: AAO85506.1AF495377 Genomic DNA Translation: AAO85507.1AF495378 Genomic DNA Translation: AAO85508.1AY651315 m RNA Translation: AAU00067.1AF468006 m RNA Translation: AAL75580.1DQ156107 m RNA Translation: AAZ81606.1DQ156108 m RNA Translation: AAZ81607.1DQ156109 m RNA Translation: AAZ81608.1DQ533840 m RNA Translation: ABF82363.1AY254700 m RNA Translation: AAP79044.1 This subsection of the 'Entry information' section provides a mnemonic identifier for a Uni Prot KB entry, but it is not a stable identifier. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'. This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein.

    Plasmodium falciparum chloroquine resistance transporter

    An ortholog of Plasmodium falciparum chloroquine., Molecular Epidemiology of Plasmodium falciparum.

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  7. Sep 25, 2009 The Chloroquine Resistance Transporter PfCRT was originally identified because mutations in this protein confer chloroquine resistance in the human malaria parasite, Plasmodium falciparum. However, the mechanism by which they do so has been the subject of ongoing debate. Martin et al. p.

    • Chloroquine Transport via the Malaria Parasite’s Chloroquine..
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    Hide 10 20 30 40 50 mkfaskknnq knsskndery reldnlvqeg ngsrlgggsc lgkcahvfkl 60 70 80 90 100 ifkeikdnif iyilsiiyls vcvmnkifak rtlnkignys fvtsethnfi 110 120 130 140 150 cmimffivys lfgnkkgnsk erhrsfnlqf faismldacs vilafigltr 160 170 180 190 200 ttgniqsfvl qlsipinmff cflilryryh lynylgavii vvtialvemk 210 220 230 240 250 lsfetqeens iifnlvlisa lipvcfsnmt reivfkkyki dilrlnamvs 260 270 280 290 300. The emergence of Plasmodium falciparum resistance to anti-malarial drugs has thwarted malaria control efforts and remains a major obstacle to malaria elimination throughout the world. Chloroquine was one of the first drugs to be used on a wide scale for the treatment of malaria. Chloroquine resistance emerged independently in different geographic regions. Plasmodium falciparum parasites have been endemic to Haiti for 40 years without evidence of chloroquine CQ resistance. In 20, we obtained blood smears for rapid diagnostic tests RDTs and filter paper blots of blood from 821 persons by passive and active case detection. P. falciparum infections diagnosed for 79 persons by blood smear or RDT were confirmed by PCR for the small.

     
  8. Dmitry_Alekseevich New Member

    A 45-year-old black female presented with no ocular or visual complaints. However, her medical history was significant for a recent diagnosis of lupus. Protecting your eyesight when taking Plaquenil Lupus. Plaquenil Toxicity" Lupus Community - Support Group Chloroquine retinopathy - Wikipedia
     
  9. Radius New Member

    Retinal Screening for Hydroxychloroquine Plaquenil Toxicity. Sep 15, 2014 In particular, chloroquine and hydroxychloroquine Plaquenil are two such medications, with the potential for retinal toxicity. Given that the retinal damage from these medications is largely irreversible, screening by a retinal specialist is critical to detect early retinal toxicity to try and limit the extent of visual loss.

    Hydroxychloroquine Plaquenil Toxicity and.
     
  10. bomh Well-Known Member

    The effect of hydroxychloroquine on glucose control and. In this context, those patients with fasting blood sugar level 100–125 mg/dL or hemoglobin A1c 5.7–6.5% were included in the study. All patients were physically examined by the physician and anthropometric parameters such as weight, height, body mass index and waist circumference were measured.

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