Most importantly, you help support continued development of this site. The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine (Plaquenil). This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day (200 bid). Hydroxychloroquine sulfate tabs 200mg and eczema Chloroquine cholesterol Plaquenil Hydroxychloroquine Eye Screening Plaquenil, also known as hydroxychloroquine, is a disease-modifying anti-rheumatic drug DMARD used to reduce inflammation and decrease pain caused by certain forms of arthritis and autoimmune disorders, such as rheumatoid arthritis and lupus. Plaquenil, hydroxychloroquine HCQ, is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis RA, systemic lupus erythematosus SLE and other inflammatory and autoimmune diseases. Of course the aim is avoid drug related retinal toxicity, which on ophthalmic examination, appears as the classic Bull’s eye change affecting the macula. Once retinal toxicity from hydroxychloroquine occurs, it is thought that the retinal changes are permanent and the disease can progress even if hydroxychloroquine is stopped for 1 to 3 years. It now solely uses real body weight (rather than ideal body weight) based on new recommendations from a 2014 study (1). Disclaimer: This tool is designed to help eye care professionals better understand the risk the of retinotoxicity from hydroxychloroquine. Please note: This calculator was modified in 9/2015. Plaquenil eye screening PATIENT FACT SHEET Hydroxychloroquine Plaquenil, The Risk of Retinal Toxicity with Plaquenil Do you need a baseline eye exam before taking hydroxychloroquineChloroquine chikungunya Macular Society Eye screening for patients taking hydroxychloroquine At this appointment, a number of photographs and scans will be taken of your retina to assess your eye health and your suitability for screening. Not all patients can use the equipment needed for screening, such as people with advanced dementia or Parkinson’s disease. Eye screening for patients taking hydroxychloroquine Plaquenil. My Take on New Ocular Screening Guidelines for Plaquenil.. Hydroxychloroquine screening - uk. Newer guidelines state that daily dose 5mg/kg of real weight/day can lead to toxicity. Retinal toxicity is irreversible and can progress after cessation of hydroxychloroquine, thus early screening is important to limit potential vision loss. Baseline screening and annual screening after five years is recommended. Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so the medication can be stopped if toxicity occurs. Currently, one of the primary functional screening tests recommended for the evaluation of Plaquenil retinal toxicity is 10-2 white stimulus automated visual fields; however, research shows Asian patients benefited from 24-2 or 30-2 visual fields, given that toxicity often manifests changes beyond the macula in these patients. 9 Because spectral-domain optical coherence tomography SD-OCT is readily accessible and able to detect early structural damage prior to clinical funduscopic findings.