Chloroquine inhibits autophagy in mice

Discussion in 'Chloroquine Drug' started by Gerda, 12-Mar-2020.

  1. is_integer New Member

    Chloroquine inhibits autophagy in mice

    Phone: (215) 746-5515; Fax: (215) 746-5511; E-mail: [email protected] in: JCI | Pub Med | Google Scholar Cancer Research Institute, University of California San Francisco Comprehensive Cancer Center, San Francisco, California, USA. Thompson, Department of Cancer Biology, Abramson Family Cancer Research Institute, 421 Curie Boulevard, 450 BRB II/III, Philadelphia, Pennsylvania 19104, USA. Chloroquine is a lysosomotropic agent that prevents endosomal acidification [1].

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    Chloroquine inhibits autophagy by blocking acidification of the lysosome, preventing fusion with the autophagosome. In a stressed cell, dependent on autophagy, this last step when blocked results in increased generation of autophagosomes, eventually undergoing either apoptotic or necrotic cell death. Damaged proteins and organelles accumulate in aged organs. We have previously reported that cardiac-specific Atg5 autophagy-related gene 5-deficient mice, in which the gene was floxed out early in embryogenesis, were born normally, and showed normal cardiac function and structure up to 10 weeks old. D HUVECs were treated by UF in the presence of the proteasome inhibitor MG132 10 μM or autophagy inhibitors bafilomycin A1 Baf, 1 μM and chloroquine CQ, 10 μM for the indicated times, and.

    This accumulation leads to inhibition of lysosomal enzymes that require an acidic p H, and prevents fusion of endosomes and lysosomes. TLR7/8-Mediated Activation of Human NK Cells Results in Accessory Cell-Dependent IFN- Production. It accumulates inside the acidic parts of the cell, including endosomes and lysosomes.

    Chloroquine inhibits autophagy in mice

    Recent insights into the function of autophagy in cancer, Inhibition of autophagy in the heart induces age-related.

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  3. These studies provide evidence that autophagy serves as a survival pathway in tumor cells treated with apoptosis activators and a rationale for the use of autophagy inhibitors such as chloroquine in combination with therapies designed to induce apoptosis in human cancers.

    • JCI - Autophagy inhibition enhances therapy-induced..
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    • Chloroquine - Wikipedia.

    Here, we show that chloroquine prevents fatality in mice with established lethal sepsis and systemic inflammation. Inhibition of autophagy with chloroquine reduced lipopolysaccharide LPS-mediated release of HMGB1, as well as HMGB1-mediated pro-inflammatory signaling responses in immune cells by inhibition of NF-κB activation. Degradation. Autophagy is involved in the pathophysiology of numerous diseases and its modulation is beneficial for the outcome of numerous specific diseases. Several lysosomal inhibitors such as bafilo-mycin A 1 BafA 1, protease inhibitors and chloroquine CQ, have been used interchangeably to block On the other hand, the very effect of chloroquine to inhibit autophagy could also sensitize kidney cells to chemotherapy, leading to acute kidney injury. Consistent with this notion, chloroquine-treated mice 60 mg/kg, daily are more vulnerable to kidney injury from ischemic–reperfusion injury than vehicle-treated mcie. This study may indicate possible additional effect of chloroquine in chemotherapy-induced kidney injury.

  4. lumpy New Member

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