Treatment for chloroquine resistant vivax malaria

Discussion in 'Chloroquine Phosphate 500 Mg' started by Filippok, 29-Feb-2020.

  1. bmp152 XenForo Moderator

    Treatment for chloroquine resistant vivax malaria


    Patients with suspected malaria should have parasitological confirmation of diagnosis with either microscopy or rapid diagnostic test (RDT) before antimalarial treatment is started. Treatment based on clinical grounds should only be given if diagnostic testing is not immediately accessible within 2 hours of patients presenting for treatment.

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    As primaquine also has weak but significant activity against blood-stage parasites 16, the radical cure regimen of chloroquine and primaquine for vivax malaria conforms to the definition of combination therapy. Combinations of chloroquine and primaquine may therefore mask low-level chloroquine resistance. Sep 15, 2001 Improved therapeutics and diagnostics should also be possible against acute vivax malaria when there is a better understanding of chloroquine resistance in P. vivax parasites. Although the action of chloroquine is probably similar in P. vivax and P. falciparum it appears that the development of chloroquine resistance involved different molecular events in these 2 species. Enhanced monitoring of P. vivax drug efficacy is needed to adapt treatment policy accordingly. This will require standardised methodologies and the development of novel tools for the more precise quantification of drug efficacy. Figure 4 shows the common causes for misdiagnosis of chloroquine sensitivity and chloroquine resistant P. vivax.

    Malaria and, as no alternative to artemisinin derivatives is expected to enter the market for several years, their efficacy must be preserved. Prompt treatment – within 24 hours of fever onset – with an effective and safe antimalarial is necessary to effect a cure and prevent life-threatening complications.

    Treatment for chloroquine resistant vivax malaria

    WHO Responding to antimalarial drug resistance, Chloroquine-Resistant Malaria The Journal of Infectious.

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  6. New Guinea or Indonesia should be treated with chloroquine, if patient does not respond, treatment should be changed to cover chloroquine-resistant P. vivax and CDC should be notified immediately Malaria Hotline number listed

    • Guidelines for Treatment of Malaria in the United States..
    • Chloroquine resistant Plasmodium vivax review Worldwide..
    • Treatment of Malaria Guidelines for Clinicians United States.

    Jul 30, 2009 Ethiopia has the highest proportion of vivax malaria, approximately 40% of all malaria infections, in contrast to African countries. Chloroquine CQ is the drug of choice for the treatment of Plasmodium vivax infection in the country, although CQ resistant P. vivax CRPv has started to challenge the efficacy of the drug. Chloroquine is the drug of choice for the treatment of non-falciparum malaria but chloroquine-resistant P. vivax has been reported in the Indonesian archipelago, the Malay Peninsula, including Myanmar, and eastward to Southern Vietnam. Although chloroquine-resistant P. falciparum predominates in Africa, it is found in combination with chloroquine-sensitive P. vivax malaria in South America and Asia. Resistance of P. vivax to chloroquine has been confirmed only in Papua New Guinea and Indonesia. For destinations where any chloroquine-resistant malaria is present, in addition.

     
  7. Nona Well-Known Member

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  8. zeboshik XenForo Moderator

    What is the role of hydroxychloroquine in the treatment of. Unless contraindicated, hydroxychloroquine should be used as adjunctive therapy in lupus nephritis because of the potential for reduction in rates of disease flare; damage accrual.including.

    Lupus and Kidney Disease Lupus Nephritis NIDDK