The authors searched MEDLINE, Cochrane data base, Ovid-Currents Clinical Medicine, Ovid-Embase: Drugs and Pharmacology, EBSCO, Web of Science, and SCOPUS using the search terms HCQ and/or pregnancy. Data were extracted onto standardized forms and were confirmed. We attempted to identify all clinical trials from 1980 to 2007 regardless of language or publication status. The odds ratio (OR) of congenital defects in live births of women taking HCQ during pregnancy was 0.66, 95% confidence intervals (CI) 0.25, 1.75. Plaquenil and discoid lupus dosage Non generic plaquenil Plaquenil Toxicity Update Chris Borgman, OD, FAAO Southern College of Optometry Memphis, TN. •“Although the mechanism of H Q toxicity is unclear, as animal. animal models of chloroquine toxicity have demonstrated inner-retinal changes lysosomal damage in the ganglion and bipolar cells as the first. Jun 08, 2017 1 An animal model is defined as a specific combination of an animal species, challenge agent refer to footnote 4 for a definition, and route of exposure that produces a disease process or. Collagen-induced arthritis CIA is a classic murine model of human rheumatoid arthritis. In CIA model, SM905 could dramatically prevent or treat arthritis, which was manifested by significantly reduced incidence, joint synovial injury, and inflammatory factors secretion 7. The OR of spontaneous abortion in women taking HCQ during pregnancy was 0.92 (95% CI 0.49, 1.72). The OR of a live birth for women taking HCQ during pregnancy was 1.05 (95% CI 0.58, 1.93). Animal model plaquenil Protective effect of hydroxychloroquine on rheumatoid., Animal Model Qualification Program Hydroxychloroquine kidney side effects Experimental model of APS. The thrombogenic mechanisms of anticardiolipin antibodies aCL have been investigated in an animal model by Pierangeli et al. A CD1 mouse model enabled the study of the kinetics of formation and dissolution of thrombus as well as the clot area in a dynamic fashion. Hydroxychloroquine as an anti-thrombotic in.. Anti-Inflammatory and Immunoregulatory Functions of.. Hydroxychloroquine overcomes tamoxifen resistance in.. These drugs have been reported to reduce the tubular secretion of methotrexate in an animal model and may enhance its toxicity. Despite the potential interactions, studies of methotrexate in patients with rheumatoid arthritis have usually included concurrent use of constant dosage regimens of NSAIDs, without apparent problems. This case of naturally passive transfer disease Severe, refractory epidermolysis bullosa acquisita compli- further demonstrates the pathogenic role of the autoantibodies as was cated by an oesophageal stricture responding to intrave- illustrated in animal model of epidermolysis bullosa acquisita. Animal Models of Lupus and Lupus Nephritis. This article reviews the commonly used murine strains for studying lupus and lupus nephritis, including strains that develop lupus spontaneously, congenic strains, induced models of lupus, as well as genetically engineered mouse models of lupus bearing transgenes or knockouts.