Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil maculopathy aao Plaquenil enlarged spleen Natural resources to make chloroquine Plaquenil cause muscle pain Before Plaquenil treatment begins. You will have a “baseline” eye exam. This measures the health of your eyes and looks for retinal or macular disease. Once a year while taking Plaquenil. After five years of Plaquenil treatment, when retina damage is likely Plaquenil Side Effects by Likelihood and Severity INFREQUENT side effects. If experienced, these tend to have a Severe expression. A Disorder Of The Retina Of The Eye; The most important affect of Plaquenil on your eye is to damage the retina at the back of your eye. Fortunately, this is very uncommon and generally only occurs in patients on high doses or patients with bad kidney function. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil does it affect the eyesight Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria, Common and Rare Side Effects for Plaquenil Oral Tumors associated with plaquenilAvn with hydroxychloroquine Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Incidence not known. Blistering, peeling, loosening of the skin; blurred vision or other vision changes; chest discomfort, pain, or tightness; cough or hoarseness; dark urine; decreased urination; defective color vision; diarrhea; difficulty breathing Plaquenil Side Effects Common, Severe, Long Term -. Plaquenil & Your Eyes. Long-Term Side Effects of Plaquenil for Rheumatoid.. Plaquenil and your eyes. A rare side effect of Plaquenil is damage to the eye's retina. The retina is the light-sensitive tissue at the back of the eye. Using Plaquenil for a long period of time may harm the retina, causing serious vision loss. People with retinal damage from Plaquenil are not aware at first that they are losing vision. Focus on Eyes Long-term Plaquenil intake can affect your vision. Taking high doses or long-term treatment of Plaquenil, an anti-malaria drug used to treat lupus, can lead to vision problems. Aug 14, 2017 Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis.