Plaquenil and hemolytic anemia

Discussion in 'Chloroquine' started by mr. Evil, 01-Mar-2020.

  1. Jekil User

    Plaquenil and hemolytic anemia


    The destruction of red blood cells is called hemolysis. Red blood cells carry oxygen to all parts of your body.

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    Chloramphenicol is known to have hemolytic effects, and there was no further evidence in the literature of an association of monotherapy chloroquine use and hemolytic anemia 12. Based on this information, monotherapy with chloroquine was considered safe to use in patients with a G6PDH deficiency 12. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. Sep 28, 2016 Of the 264 patients with normal G6PD levels, 14 5% had hemolytic anemia at some point, caused by TTP n=4, autoimmune hemolytic anemia n=9, and pure red cell aplasia n=1. Conclusion This is the largest study to date evaluating G6PD deficiency with concurrent use of HCQ.

    When you have anemia, your blood can’t bring enough oxygen to all your tissues and organs. If you have a lower than normal amount of red blood cells, you have anemia.

    Plaquenil and hemolytic anemia

    What is the correct way to discontinue use of plaquenil?, Hydroxychloroquine DermNet NZ

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  4. The ADAMTS13 level was not diagnostic of thrombotic thrombocytopenic purpura. Based on the timing of the anemia after stopping HCQ, and despite 3 days of HCQ use during a severe lupus flare, we concluded that the hemolytic anemia was not likely caused by HCQ.

    • Examination of Hydroxychloroquine Use and Hemolytic Anemia..
    • Hydroxychloroquine Is Not Associated with Hemolytic Anemia in..
    • Plaquenil - FDA prescribing information, side effects and uses.

    Glucose-6-phosphate dehydrogenase G6PD deficiency—May cause hemolytic anemia in patients with this condition. Kidney disease or Liver disease—Use with caution. The effects may be increased because of the slower removal of the medicine from the body. Description and Brand Names; Proper Use; Portions of this document last updated Feb. 01, 2020 Hemolytic anemia is a disorder in which red blood cells are destroyed faster than they can be made. The destruction of red blood cells is called hemolysis. Red blood cells carry oxygen to all parts of your body. If you have a lower than normal amount of red blood cells, you have anemia. Among glucose-6-phosphate dehydrogenase-deficient patients with rheumatic disease, hydroxychloroquine was not linked with hemolytic anemia, according to a recently published analysis.

     
  5. Dimasseo Moderator

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  6. vladimir74 New Member

    I have been on Plaquenil (well the generic form-- hydroxychloroquine) since October, and for the past about 2 weeks, I have been SEVERELY itchy. Plaquenil and SEVERELY ITCHY SKIN! PLZ HELPPP. - Inspire Hydroxychloroquine Plaquenil Side Effects & Dosage for. Plaquenil Side Effects on Your Eyes and Vision
     
  7. digital User

    Minocycline + Plaquenil + Tinidazole Good article on this. May 02, 2014 This minocycline + plaquenil + tinidazole has worked so effectively well for me I think more people should be aware of it! Here is an article that supports it, also it even cures Lyme related MS.

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  8. kbc Guest

    Aralen, Chloroquine phosphate chloroquine dosing. QT interval prolongation, torsades de pointes, and ventricular arrhythmias reported; risk is greater if chloroquine is administered at high doses; fatal cases reported; use with caution in patients with cardiac disease, a history of ventricular arrhythmias, uncorrected hypokalemia and/or hypomagnesemia, or bradycardia 50 bpm, and during concomitant administration with QT interval prolonging agents due to potential for QT interval prolongation

    Aralen Chloroquine Uses, Dosage, Side Effects.