In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Plaquenil anti inflammatory How dispose of chloroquine safely Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Banded or diffuse pigmentation of nails often occurs; Amiodarone Blue-grey pigmentation in sun-exposed areas face and hands Photosensitivity occurs in 30-57% of patients whilst 1-10% show skin pigmentation; Skin pigmentation is reversible but may take up to one year for complete resolution after the drug has been stopped; NSAIDs A known side effect of using antimalarials long term is dark patches on the skin. The Lupus Encyclopedia Thomas Jr. 2014 says this 'One of the potential long-term side-effects of using anti-malarial medications such as hydroxychloroquine Plaquenil, chloroquine, and quinacrine is the development of dark-colored patches on the skin. Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Plaquenil skin pigment Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Drug-induced hyperpigmentation DermNet NZ Color dx test results in plaquenil toxicityPlaquenil como funcionaChloroquine vs quinine Sep 13, 2019 Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur. Plaquenil Side Effects Common, Severe, Long Term -. Hydroxychloroquine and skin darkening Hi All. - LUPUS UK. Will you have Skin hyperpigmentation with Plaquenil - eHealthMe. Hydroxychloroquine Plaquenil is not a new therapy. It has been used in rheumatology for decades and it's proven a very useful medication. In my clinic, I mainly use it for these 3 indications The skin lesions were macular or patchy, some well and others poorly demarcated, with a hyperpigmentation of gray to black discoloration, generally annular, but some with irregular morphology. They were flat without induration or scaling Figure 1. Aug 18, 2011 Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong.