Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine: Incidence not known Some side effects of chloroquine may occur that usually do not need medical attention. Hydroxychloroquine and inflexizumab Quinine sulfate allergy is it okay to take plaquenil Hydroxychloroquine in canada Of note, chloroquine and hydroxychloroquine are considered to be safe and side-effects are generally mild and transitory. However, the margin between the therapeutic and toxic dose is narrow and chloroquine poisoning has been associated with cardiovascular disorders that can be life-threatening Frisk-Holmberg et al. 1983. Chloroquine is an aminoquinoline used for the prevention and therapy of malaria. It is also effective in extraintestinal amebiasis and as an antiinflammatory agent for therapy of rheumatoid arthritis and lupus erythematosus. Overdose. Chloroquine is very toxic in overdosage; overdosage is extremely hazardous and difficult to treat. Urgent advice from the National Poisons Information Service is essential. Life-threatening features include arrhythmias which can have a very rapid onset and convulsions which can be intractable. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Chloroquine phosphate toxic CHLOROQUINE PHOSPHATE TABLETS, USP 250 MG and 500 MG, Chloroquine - LiverTox - NCBI Bookshelf Where is sandoz plaquenil producedChloroquine lysosome inhibitor mechanismPlaquenil induced rashPlaquenil coupons discounts Antacids and kaolin can reduce the absorption of chloroquine; separate by 4 hours. Concomitant use of cimetidine should be avoided. Chloroquine phosphate is calculated as the base. Each 250 mg tablet of chloroquine phosphate is equivalent to 150 mg base and each 500 mg tablet of chloroquine phosphate is equivalent to 300 mg base. CHLOROQUINE PHOSPHATE Aralen, HYDROXYCHLOROQUINE.. CHLOROQUINE Drug BNF content published by NICE. SAFETY DATA SHEET Page 1 of 6 Chloroquine phosphate Revision. Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Each tablet contains 500 mg of Chloroquine phosphate USP, equivalent to 300 mg Chloroquine base. Inactive Ingredients colloidal silicon dioxide, dibasic calcium phosphate, hydroxypropylmethylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate80, pregelatinized starch, sodium starch glycolate and titanium dioxide. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin.