Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine monitoring parameters Can you rheumate with plaquenil Plaquenil immune system Hydroxychloroquine is excreted both renally and hepatically. The amount of hydroxychloroquine excreted in the urine as unchanged drug ranges from 6% to 60% median 23%, and 17% is excreted in the urine as metabolized drug. Interaction. You can also ask your pharmacist to check for drug interactions. What are the potential side effects of hydroxychloroquine? Hydroxychloroquine is a relatively well tolerated medicine. The most common adverse reactions. reported are stomach pain, nausea, vomiting, and headache. These side effects can often be lessened by taking hydroxychloroquine with food. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. If you have lupus, it may also improve the rash. It may be as long as 12 weeks before you notice the benefits. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Drug interactions between hydroxychloroquine Hydroxychloroquine Side Effects, Dosage, Uses, and More, Medicines for the Prevention of Malaria While Traveling. Plaquenil mot malariaPlaquenil side effects anxiety Learn about drug interactions between etanercept subq and hydroxychloroquine oral and use the RxList drug interaction checker to check drug combinations. Drugs A-Z Pill Identifier Supplements Symptom Checker Diseases Dictionary Media Etanercept subq and hydroxychloroquine oral Drug Interactions.. Hydroxychloroquine Side-effects, uses, time to work. Digoxin oral and hydroxychloroquine oral Drug Interactions.. A list of drugs that interact with Hydroxychloroquine. Hydroxychloroquine is predicted to increase the risk of haematological toxicity when given with penicillamine. Use WebMD’s Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more.