While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "Hydrochloroquine (Plaquenil) has been a blessing for me. Plaquenil dmard Chloroquine in lentiviral transduction Artemisinin and chloroquine structure Plaquenil and ovarian cancer Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. What next if plaquenil doesn't work? Support Forums. Yea, I am allergic to sulfa or I'd be on celebrex right now. I wish the plaquenil was working but it's not. I feel so bad every day. Prednisone ran my blood sugar up but I felt great on it, not that you want to take it for too long. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues. I happen to run out of my medication and fail to be in a hurry to get a refill because I had convinced myself that it wasn't working anyway. I do occasionally experience dry eyes and a little scalp itch but asserting that it's caused by Hydrochloroquine would be anecdotal at best. It took about 5 weeks to take effect but my RA is basically a non factor now. Plaquenil not working Hydroxychloroquine Plaquenil thread COVID19, What next if plaquenil doesn't work? Plaquenil and tick bitesDistribution of malaria and chloroquine-resistantPlaquenil dose calculatorSjogren's syndrome and plaquenil A rare side effect of Plaquenil is damage to the eye's retina. The retina is the light-sensitive tissue at the back of the eye. Using Plaquenil for a long period of time may harm the retina, causing serious vision loss. People with retinal damage from Plaquenil are not aware at first that they are losing vision. What Is Plaquenil? - American Academy of Ophthalmology. Stopping plaquenil. DailyStrength. Aftermath of not taking Plaquenil! - YouTube. Re Plaquenil not working anymore Lizzy, I took 400mg 200 twice a day for 16-18 months forget exact duration, then was reduced to 200 mg daily. But right from the start, I also needed NSAID's for pain. Plaquenil takes quite a long time to get to its peak effectiveness depending on what you read, anywhere from 3 months to a year. Unless you are having significant side effects, try to give it at least 6 months before you decide it doesn't work for you. Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria chloroquine-resistant. The United States Center for.