Chloroquine resistant malaria prophylaxis

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  1. SkyGSN New Member

    Chloroquine resistant malaria prophylaxis


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    Chloroquine is the drug of choice for people who travel to these areas; however, resistance to chloroquine is now widespread in all areas of the world where malaria is endemic, but it is still an effective choice for prophylaxis in travelers to Mexico, the Caribbean, Central America, Argentina. Malaria Information and Prophylaxis by Country; Country Areas with Malaria Drug Resistance 2 Malaria Species 3 Recommended Chemoprophylaxis 4 Key Information Needed and Helpful Links to Assess Need for Prophylaxis for Select Countries Malaria Information and Prophylaxis by Country; Country Areas with Malaria Drug Resistance 2 Malaria Species 3 Recommended Chemoprophylaxis 4 Key Information Needed and Helpful Links to Assess Need for Prophylaxis for Select Countries; Gabon All Chloroquine P. falciparum 90%, P. malariae, P. ovale, P. vivax 10% combined

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Chloroquine resistant malaria prophylaxis

    CDC - Malaria - Travelers - Malaria Information and Prophylaxis, by Country, Malaria Information and Prophylaxis, by Country B - CDC

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  3. Chloroquine, a 4-amino-quinoline, has been the backbone of antimalarial therapy and prophylaxis for 50 years. The incessant spread of resistance to chloroquine by P. falciparum is leading to a resurgence of malaria in most endemic areas.

    • Chloroquine - an overview ScienceDirect Topics.
    • CDC - Malaria - Travelers - Malaria Information and..
    • Where is chloroquine resistant malaria ZCARR.

    In areas where there is chloroquine-resistant malaria, either atovaquone/proguanil Malarone, mefloquine Lariam or doxycycline can be used for prophylaxis. Primaquine is a good alternative, but requires a G-6-PD screening blood test. Blood stage prophylaxis is the most common type of prophylaxis in use. Chloroquine, was the first drug in this group to be extensively used. It was introduced in the early 1950’s for the prevention of both falciparum and vivax malaria. While chloroquine-resistant P. falciparum appeared quite quickly, in the late 1950’s, chloroquine-resistant P. vivax presented only in the late 1980’s. Prophylaxis of malaria in geographic areas where resistance to Chloroquine is not present. Treatment of extraintestinal amebiasis. Chloroquine phosphate tablets do not prevent relapses in patients with vivax or ovale malaria because it is not effective against exoerythrocytic forms of the parasites.

     
  4. in3t XenForo Moderator

    Nonaqueous titration is the titration of substances dissolved in solvents other than water. Non Aqueous Titration - Definition, Theory, and Types of Non. Non-aqueous titration - World Health Organization EXTRACTIVE VISIBLE SPECTROPHOTOMETRIC DETERMINATION OF.
     
  5. selif Moderator

    Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Plaquenil Hydroxychloroquine may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Headache, dizziness, seizure, ataxia and extrapyramidal disorders such as dystonia, dyskinesia, and tremor have been reported with this class of drugs.

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