It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Plaquenil otc Chloroquine phosphate fish medication Apr 10, 2019 Plaquenil can cause serious liver or heart problems, especially if you use certain medicines at the same time, including other medicines to treat malaria; an antibiotic or antifungal medicine; Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine is metabolized and secreted by both the liver and the kidneys. Therefore, disturbed renal or hepatic function might reduce HCQ clearance and increase the propensity for toxicity. Older age may also be associated with increased risk of macular toxicity, possibly due to the pre-existence of age-related macular changes that might not allow for the identification of early signs of toxicity. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Is plaquenil toxic to the liver Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis., Hydroxychloroquine-Induced Retinal Toxicity - American. American academy of ophthalmology plaquenil guidelinesDrug interaction plaquenil and doxycyclineChloroquine cancer treatmentIs chloroquine a lysosomePronounce hydroxychloroquine Use of plaquenil for more than 5 years; Obesity; Pre-existing retinal disease; Renal or liver failure All patients should have a “baseline” screening appointment PRIOR to starting plaquenil or other “high risk” medications. AFTER plaquenil is started, patients should be screened YEARLY. Dr. Noskow's Case Report Plaquenil Toxicity - Hollywood Eye Institute. Retinal Physician - Hydroxychloroquine Maculopathy An Update on.. Hydroxychloroquine - Wikipedia. Liver function test abnormal is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Enbrel, and have Osteoporosis. Hydroxychloroquine therapy has not been associated with liver function abnormalities and is an extremely rare cause of clinically apparent acute liver injury. Hydroxychloroquine is a derivative of chloroquine that has both antimalarial and antiinflammatory activities and is now most often used as an antirheumatologic agent in systemic lupus erythematosis and rheumatoid arthritis. This condition does not cause symptoms and is reversible with cessation of the medication. The finding of corneal verticillata bares no correlation with retinal toxicity and is not an indication to stop the medication 1. The hallmark of hydroxychloroquine toxicity is bilateral pigmentary retinopathy 1.