It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Chloroquine phosphate fowlr Plaquenil and magnesium May 15, 2018 Another more notable event was the incidence of corneal verticillata, or vortex keratopathy, which was present in about 21% of patients given once-a-day Rhopressa at the one-month mark in the four trials Figure 1. 2 These brownish/grayish subepithelial corneal deposits radiate in the central cornea in a “whorl” pattern, and are a notable side effect in patients taking a number of. Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is. Retinal!toxicity.and!it!has!largely!replaced!chloroquine!as!a!treatment!ofinflammatory!disease. Unfortunately.the!retinal!damage!from!these!medications. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Cornea verticillata plaquenil Plaquenil Maculopathy, Multimodal Imaging in Plaquenil Toxicity Plaquenil dosage for sarcoidosisIs hydroxychloroquine a nsaidNight swets plaquenilHydroxychloroquine causing neuropathy Vortex keratopathy, or corneal verticillata, is a common side effect of a number of systemic medications—e.g. amiodarone, aminoquinolones, indomethacin, tamoxifen, atovaquone and tilorone—and results from the intralysosomal accumulation of lipids. This condition presents with golden-brown deposits in a whorl-like pattern normally seen. When ‘Collateral Damage’ Strikes the Cornea. Plaquenil toxicity-eye rounds edited FINAL WARD. Amiodarone-Induced Vortex Keratopathy NEJM. The presence of corneal verticillata does not correlate with retinal toxicity. Corneal verticillata is less common with HCQ than CQ 7, 21, 22. Retinopathy. Although rare, retinopathy is the major concern expressed by most patients and clinicians using HCQ. Corneal verticillata. Like a number of other drugs, HCQ and CQ can cause corneal verticillata also known as vortex keratopathy. These epithelial changes arise due to precipitation of the drug, typically forming a whorl-like pattern that is reversible with drug cessation. Feb 16, 2016 Systemic lupus erythematosus SLE is a chronic multisystem autoimmune disease. The eye is frequently involved in SLE.1 The disease may cause ocular involvement by several mechanisms including immune complex deposition in the basement membrane of endothelial cells of the small blood vessels.1 Ocular complications have been reported in up to one-third of patients with SLE.2 Ocular.