Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Is plaquenil a sulfa drug Hydroxychloroquine scleroderma This is a reivew of how effective Plaquenil hydroxychloroquine sulfate is for Systemic sclerosis scleroderma and for what kind of people. The study is created by eHealthMe from 11 Plaquenil users and is updated continuously. Some medications, such as plaquenil and minocycline, can cause permanent dark skin plaques, which resemble black and blue marks similar to morphea scleroderma. Cosmetically, pigmentation differences can be covered up with corrective cosmetics, such as Dermablend. Drug-Induced Hyperpigmentation caused by Minocycline Minocin Antibiotic I take Plaquenil for MCTD and it really helps my joint pain but it doesn't do anything for the more scleroderma - like features like Raynauds and GI issues, and It will not help Scleroderma lung problems. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Scleroderma plaquenil Scleroderma -, Systemic Scleroderma Skin Involvement Hyperpigmentation and. Plaquenil for early raWill plaquenil treat lupus and rheumatoid arthritis Scleroderma is thought to be an autoimmune disease. This means the symptoms are caused by the body attacking its own healthy tissues. Genes play a role in the disease, but the environment also plays a role. Family members of people with scleroderma have a mildly increased risk of developing scleroderma. Scleroderma Cedars-Sinai. Plaquenil for scleroderma? - Scleroderma - Inspire. Lupus and Scleroderma Overview - Lupus International. Scleroderma sklair-oh-DUR-muh is a group of rare diseases that involve the hardening and tightening of the skin and connective tissues. Scleroderma affects women more often than men and most commonly occurs between the ages of 30 and 50. While there is no cure for scleroderma, a variety of treatments can ease symptoms and improve quality of life. Systemic sclerosis scleroderma is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 10+ years, also take medication Lasix, and have Osteoporosis Immunosuppressants fall under a category of drugs referred to as DMARDs Disease-Modifying Anti-Rheumatic Drugs. ISN. Scleroderma Treatments and Clinical Trials ISN. Effect of disease-modifying anti-rheumatic drugs DMARDs on bone structure and strength in psoriatic arthritis PsA patients.