So far I have no more energy than when I first started and has developed neuropathy which I have just found out from Web MD that this neuropathy is one of the side effects of this med! Saying that by stopping this it would take another 6 months to build up the benefit. There are other meds that can help with what you are experiencing, and if your doctor didn't address that then I would seek out a second opinion... Please don't stop your plaquenil until you are sure it is the right thing to do and in your best interest. Plaquenil and complement levels Plaquenil lupus how long to work Chloroquine phosp hat e Plaquenil ® hydroxychloroquine – New Warnings • On January 27, 2017, the FDA approved new updates to the. Warnings. section of the Plaquenil hydroxychloroquine drug label regarding cardiac effects, including cardiomyopathy and QT prolongation, and hypoglycemia. • Plaquenil is indicated for the treatment of uncomplicated malaria due to Conditions such as systemic lupus erythematosus SLE/Lupus. Hydroxychloroquine is also an antimalarial medicine used to prevent and treat malaria and other parasitic infections. It is not used routinely now for this purpose because of resistance by the parasites. It is not clear how hydroxychloroquine works in INTRODUCTION Hydroxychloroquine HCQ is an alkalinizing lysosomatropic drug that accumulates in lysosomes where it inhibits some important functions by increasing the pH. HCQ has proved to be effective in a number of autoimmune diseases including systemic lupus erythematosus SLE. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. Or maybe another doctor if you're not comfortable w/your current one. When to stop hydroxychloroquine in sle Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, ATIENT NFORMATION ON HYDROXYCHLOROQUINE Qt with chloroquine phosphateBest malaria medication for chloroquine resistant malariaJohn hopkins research on plaquenil If you are taking hydroxychloroquine for symptoms of rheumatoid arthritis, your symptoms should improve within 6 months. If your rheumatoid arthritis symptoms do not improve, or if they worsen, stop taking the drug and call your doctor. Once you and your doctor are sure the drug works for you. Hydroxychloroquine MedlinePlus Drug Information. Hydroxychloroquine in systemic lupus erythematosus SLE.. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. I was put on Plaquenil for RA as I was being dx for lupus. I am very mild. My rhuemy wants me to stop every time I have an infection. When it is gone she said I can resume at my own pace. Take into consideration I only take Plaquenil and ibuprofen 800mg. My symptoms came back after two weeks of being off it. Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. The prognosis for patients with systemic lupus erythematosus SLE has improved significantly, with 20-year survival now approximately 80% owing partly to effective treatment. SLE treatment has evolved from the use of conventional drugs such as hydroxychloroquine.