IV/IM: Initial dose: 20 to 40 mg IV (slowly over 1 to 2 minutes) or IM once; may repeat with the same dose or increase by 20 mg no sooner than 2 hours after the previous dose until the desired diuretic effect has been obtained. Maintenance dose: Administer the dose that provided the desired diuretic effect once or twice a day. Use: Treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome, especially when an agent with greater diuretic potential is desired. Oral: Initial dose: 20 to 80 mg orally once; may repeat with the same dose or increase by 20 or 40 mg no sooner than 6 to 8 hours after the previous dose until the desired diuretic effect has been obtained. Maintenance dose: Administer the dose that provided the desired diuretic effect once or twice a day (e.g., at 8 am and 2 pm). Maximum dose: 600 mg/day in patients with clinically severe edematous states Comments: -Edema may be most efficiently and safely mobilized by giving this drug on 2 to 4 consecutive days each week. -When doses greater than 80 mg/day are given for prolonged periods of time, careful clinical observation and laboratory monitoring are particularly advisable. can you buy generic lexapro Thought to inhibit sodium and chloride reabsorption from ascending loop of Henle and distal renal tubules. For maintenance, dosage may be reduced in some patients or carefully titrated upward to 600 mg P. Increases potassium excretion and plasma volume, promoting renal excretion of water, sodium, chloride, magnesium, hydrogen, and calcium. 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